Monoolein cubic phase containing disulfide proteinoid and its reduction-responsive release property

ABSTRACT

Monoolein (MO) cubic phase, which can release its payload in answering to reducing condition, was prepared by including a disulfide proteinoid composed of Asp, DL-leucine (Leu), and dithiodipropionic acid (DTPA) in its water channel. On the TEM micrograph, the cubic phase could accommodate the proteinoid with no change in its bilayer structure. The phase transition temperature of the cubic phase was about 58.7°C, and it was little affected by the proteinoid. The release degree of allura red loaded in the cubic phase was higher at a higher dithiothreitol (DTT) concentration. The proteinoid would be broken down by the reducing agent, facilitating the release.

GRAPHICAL ABSTRACT

KEYWORDS:

• Allura red
• condition
• cubic phase
• disulfide proteinoid
• reducing
• release

Additional information

Funding

This work was supported by the Technological Innovation R&D Program (S2406238) funded by the Small and Medium Business Administration (SMBA, Korea).