Cyclodextrin nano-organogels as a delivery vehicle for peppermint essential oil to enhance its physico-chemical properties and skin photoprotective performance

Abstract

Acute sun exposure could lead to erythema and inflammation. This Investigation aims to determine the efficacy of the complexation of peppermint oil (PO) with cyclodextrin in enhancing its physicochemical properties. Nano-organogels were prepared by direct hot melting method. Cyclodextrin (CD) PO was prepared by co-lyophilized method and included in F6. The particle size values were all below 150 nm. F6 polymeric showed high antioxidant activity, in vitro SPF, and stability. CD nano-organogel showed the least release and the highest skin deposition values. This high skin deposition is assured by confocal microscopy. Histology revealed its anti-inflammatory effect against acute UV irradiation. PO CD nano-organogel demonstrates a promising modality for anti-inflammatory therapy against UV irradiation.

Graphical Abstract

Keywords:

• peppermint oil
• nano-organogels
• cyclodextrin
• photoprotection
• confocal microscopy
• skin deposition

Author contributions

ESS: participate in practical work, writing, editing, and submission process. SIS: aid in data collection and writing. SAT: aid in practical work, data collection, presenting figures and tables.

Ethics statement

All institutional and national guidelines of the medical research ethics committee of the national research center, Egypt for the care and use of laboratory animals were followed (Approval Number: 64410112021).

Consent form

Not applicable.

Disclosure statement

The authors report there are no competing interests to declare

Funding

This research received no specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Data availability statement

The datasets generated during and analyzed during the current study are available from the corresponding author on reasonable request.