Abstract
“What you freely assert, I freely deny. Sustain your case!” Challenged by a Jesuit priest to think with evidence and logic, Edmund Daniel Pellegrino began a lifelong trajectory to become a leading American bioethicist. He ardently urged many physicians and scientists along the way to think deeply about ethics and the ways our lives are shaped by uncomfortable debates. This profile takes the reader through the life of this sorely missed intellectual giant from his early days in New Jersey to the end of his career in Washington, DC.