Recent Developments in the Area of Thionation Methods and Related Synthetic Applications

Abstract

This review article represents a collection of references explicit to all thionation methods and related thiocarbonyl derivatives found and described in the literature during the period 1985 to mid-1991. The classification of this review is based on the thionation reagent in the first instance and then on the type of transformation and the type of thiocarbonyl obtained. Special emphasis was also put on new thionation reagents which are described in Section 2. The synthetic applications of previously known thionation reagents, such as Lawesson's reagent and tetraphosphorus decasulfide for example, are presented separately through Sections 3 to 8 with as much experimental details as available. This collection of references was performed with the Chemical Abstract and the CAS on-line system with key words such as thioamide, thiolactam, thiopeptide, thionoester, dithioester or thioaldehyde and those given below. Other references were found by screening (1) synthetic organic chemistry book series, (2) the issues of several journals for the year 1991 and (3) the reference sections of the articles found.

Key Words:

• Lawesson's reagent
• sulfuration
• thio analogs
• thiocarbonyl
• thionation