Abstract
Heterocyclic compounds are of paramount importance in essentially all fields of chemistry and in our daily life. Therefore, the synthesis and modification of such compounds is a constantly expanding field in synthetic chemistry. Recent developments of functionalization of heterocycles by means of cyclometallation (also called chelation-assisted functionalization), both stoichiometric and catalytic, indicate that this strategy displays enormous potential. In particular, this method facilitates considerably the synthesis of functionalized heterocycles in a regioselective (site-selective) manner, and also provides novel types of synthetic transformations.
ACKNOWLEDGEMENTS
Funding by the Ministerio de Economia y Competitividad (Spain, Project CTQ2011-22589) and Gobierno de Aragón (Spain, group E97) is gratefully acknowledged. L. C. thanks Consejo Superior de Investigaciones Científicas (Spain) for a Juan de la Cierva contract.