Tailoring MOFs to Biomedical Applications: A Chimera or a Concrete Reality? The Case Study of Fe-BTC by bio-friendly Mechanosynthesis

ABSTRACT

We point-out an exceptional tailorability of iron(III) trimesate metal-organic framework to bio-friendly conditions. This is particularly attractive in sight of one-pot immobilization of biomolecules for biomedical applications. Synthesis is carried out via mechanochemical approach under green, biocompatible conditions without additional solvents, in just 1 hour, at room temperature. Solvents are proven to be unnecessary to build the framework, in contrast to solution-based methods. Microstructure and thermal stability of the material are not affected by pH. Conversely, textural properties can be tuned by simply varying the amount of base.

Graphical abstracrt

Acknowledgments

This work was supported by the FdS 2020 - Progetti biennali dell’Università di Cagliari funded by Fondazione di Sardegna- Smart supramolecular Materials for Anion sensing and Water Remediation (SMAWRT). We acknowledge CeSAR (Centro Servizi d’Ateneo per la Ricerca) of the University of Cagliari, Italy for the XRPD and SEM experiments performed with a Bruker D8 Advance Diffractometer and a FEI Quanta 200 Microscope, respectively.

Disclosure statement

No potential conflict of interest was reported by the author(s)