SARS-CoV-2 origins: zoonotic Rhinolophus vs contemporary models

ABSTRACT

The question of the origin of coronavirus spread like wildfire ever since it wreaked havoc among humankind, and ever since the scientific community has worked tirelessly to trace the history of the virus. In this review, we have tried to compile relevant literature pertaining to the different theories of origin of SARS-CoV-2, hopefully without any bias, and we strongly support the zoonotic origin of the infamous SARS-CoV-2 in bats and its transfer to human beings through the most probable evolutionary hosts, pangolins and minks. We also support the contemporary ‘Circulation Model’ that simply mirrors the concept of evolution to explain the origin of the virus which, the authors believe, is the most rational school of thought. The most recent variant of SARS-CoV-2, Omicron, has been taken as an example to clarify the concept. We recommend the community to refer to this model for further understanding and delving deep into this mystery of the origin of SARS-CoV-2.

KEYWORDS:

• Circulation model
• COVID-19
• pangolins
• laboratory leak
• bioweapon
• zoonosis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research has been funded by Scientific Research Deanship at University of Ha’il - Saudi Arabia through project number MDR-22020