A critical review on nanomaterial based therapeutics for diabetic wound healing

ABSTRACT

Diabetes mellitus is a chronic endocrine disease that occurs mostly in the state of hyperglycemia (elevated blood glucose level). In the recent times, diabetes is listed under world’s utmost critical health issues. Wound treatment procedures are complicated in diabetic individuals all over the world. Diabetic wound care not only involves high-cost, but also the primary cause of hospitalization, which can lead to amputation thereby reducing diabetic patient life expectancy. To lower the risk of amputation, wound healing requires the development of effective treatments. Traditional management systems for Diabetes are frequently chastised due to their high costs, difficulties in maintaining a sustainable supply chain and limited disposal alternatives. The worrisome rise in diabetes prevalence has sparked a surge of interest in the discovery of viable remedies to supplement existing treatments. Nanomaterials wound healing has a lot of potential for treating and preventing wound infections and it has recently gained popularity owing to its ability to transport drugs to the wound area in a regulated fashion, potentially overpowering the limits of traditional approaches. This research assessed several nanosystems, such as nanocarriers and nanotherapeutics, to explore how they can benefit in diabetic wound healing, with a focus on current obstacles and future prospects.

KEYWORDS:

• Diabetes mellitus
• wound infection
• wound healing
• nanomaterials
• nanotherapeutics

Acknowledgment

The authors express their gratitude to the Vice Chancellor, Director General of Research and Development of the KIIT Deemed to be University, as well as the Department Head. The Ministry of Mines, Government of India, has sponsored this research.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors reported there is no funding associated with the work featured in this article.

Notes on contributors

Swati Sucharita Singh

Ms. Swati Singh is working on her PhD at the Kalinga Institute of Industrial Technology (from 2020) with the help of Dr. Amrita Mishra. She got her MSc in Applied Microbiology in 2020 from the KIIT School of Biotechnology at the Kalinga Institute of Industrial Technology in Bhubaneswar, India. She also got her BSc in Biotechnology (Honors) in 2018 from the Trident academy of creative technology in Bhubaneswar, India.

Susanta Kumar Behera

Mr. Susanta Behera is a well-known scientist who has been employed with IMGENEX India Pvt. Ltd. in Bhubaneswar for the past ten years. He has an overall of 12 years of experience in the field of biotechnology; this includes 1 and a half years of research experience in infection immunology (South Korea), 4 years of industrial experience in production of polyclonal antibodies, Purification, and Conjugation, and the last 5 years of industrial experience in production of monoclonal antibody. Mr. Behera has had 12 papers published in a variety of SCI publications that have a high impact factor.

Suchita Rai

Dr. Suchita B. Rai is a Principal Scientist at the Jawaharlal Nehru Aluminium Research Development and Design Centre located in Wadi, Nagpur. She works in the Bauxite -Alumina Division. The primary focuses of Dr. Suchita's study include the creation of specialised alumina products, the mineral alumina itself, the technological analysis of bauxite, and the application of red mud. Have applied for two patents related to the development of smelter grade alumina from boehmite and low soda alumina hydrate. projects for virtually all alumina refineries were successfully completed. To this day, she has published to more than 25 articles that have been published in journals that are indexed by SCI or SCOPUS. She has been recognised as the top scientist by a number of different organisations.

Suraj K Tripathy

Dr. Suraj Kumar Tripathy is a well experienced member in the field of wastewater treatment. Recently he has developed novel strategy for wastewater recycling by removing Chromium [Cr(III)] from water, utilizing the treated water for agricultural purposes and the saturated adsorbent used as the catalyst for p-nitrophenol reduction was successfully incorporated for sustainable environmental application. Removal of Cr(III) by adsorption on Cymbopogon flexuosus waste material entrapped within sodium alginate beads was investigated. Moreover he has introduced an optimization methodology to investigate for optimization of process parameters during removal of Cr(III) from aqueous solution. His generous knowledge on wastewater treatment technology will lead us to design and demonstrate the developed set-up to the industry. In addition to that well experienced on IPR generation will lead to transfer the technology to the interested company. Dr. Tripathy published more than 70 papers in several high impact SCI/SCOPUS journals also filed 6 patents on his name. He has awarded as Eminent Scientist of the Year 2021 from National Environmental Science Academy.

Sankha Chakrabortty

Dr. Sankha Chakrabortty, Assistant Professor, School of Biotechnology/Chemical Technology, KIIT Deemed to be University, is a distinguished researcher in the fields of Environmental Engineering, Membrane Technology, and Green Technology. He has published his study in more than 37 SCI/SCOPUS indexed journals with high impact factors, and he has filed 8 patents based on his research advancement, two of which were awarded/granted. Dr. Chakrabortty also published 20 book chapters. As a Co-Editor, he has recently published one book. For his research contributions, he has received 14 awards/achievements and certificates from various organisations. In 2015, he got the SPRINGER publisher's ”Best Paper Award-2015,” and last year, he received an international organization's ”Best Researcher Award-2020,” as well as the National Environmental Science Academy's ”NESA Young Scientist of the Year 2020”. In addition to that Dr. Chakrabortty bagged another award under the category of ”STE-Young Scientist Award (Faculty Category)” and KIIT University appreciated him work for his outstanding research work. Recently Dr. Chakrabortty awarded as Hiyoshi Young Leaf Award-2022 from Hiyoshi Corporation, Japan.

Amrita Mishra

Dr. Amrita Mishra, Assistant Professor and a leading researcher in the field of Bio-Technology at the KIIT Deemed to be University's School of Biotechnology. Dr. Mishra earned her Ph.D. and Post-Doc from Chonbuk National University in Jeonju, South Korea's Department of Food Science and Technology. She has published his study in more than 31 SCI journals with a high impact factor, and she has also filed two patents based on her research. Dr. Mishra has also written two book chapters. For her scientific endeavours, she has received three awards/achievements/fellowships from various organisations. Dr. Mishra is the Principal Investigator (PI) for three GOI-funded projects, one of which was completed successfully. Dr. Mishra awarded as best women scientist of the year-2021 from National Environmental Science Academy, India.