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ABSTRACT
Objective. To analyze the clinical effect of prescription used for invigorating spleen, reinforcing kidney and warming yang combined with calcium dobesilate to treat senile diabetic nephropathy (DN). Methods. The clinical data of 110 elderly patients with DN in our hospital from November 2020 to November 2021 were selected for retrospective analysis, and they were divided into the observation group (OG, n = 55) and the control group (CG, n = 55) according to the principle of random grouping. The CG received conventional therapy and calcium dobesilate, and the OG received conventional therapy, calcium dobesilate and prescription used for invigorating spleen, reinforcing kidney and warming yang to evaluate the clinical value of different treatment programs by comparing their clinical indicators after treatment. Results. The total effective rate of clinical treatment in the OG was clearly higher than the CG (P < 0.05). The blood glucose indexes, and the levels of ALB and RBP in the OG were visibly lower than the CG after treatment (P < 0.001). After treatment, the average levels of BUN and Cr in the OG were visibly lower than the CG (P < 0.001), while the average eGFR level was significantly higher than the CG (P < 0.001). Conclusion. The prescription used for invigorating spleen, reinforcing kidney and warming yang combined with calcium dobesilate is a reliable method to improve the hemorheology indexes and renal function of DN patients, which benefits patients, and further studies are helpful to establish a better solution for such patients.
Disclosure statement
The authors do not have Conflicts of Interest to declare.
Data availability statement
Data to support the findings of this study is available on reasonable request from the corresponding author.
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Notes on contributors
Lin Zhu
Lin Zhu, Master of Medicine. Engaged in endocrinology clinical work of integrated traditional Chinese and western medicine for more than 20 years, and has rich clinical diagnosis and treatment experience in diabetes and its complications, especially diabetes nephropathy, diabetes peripheral neuropathy, and is good at the treatment of thyroid diseases, obesity, menopausal syndrome and other diseases.
Jianqun Zhao
Jianqun Zhao, Bachelor’s degree. Engaged in clinical work of traditional Chinese medicine for more than 20 years, mainly focusing on the treatment of diabetes and its complications with traditional Chinese and western medicine. Research direction: Mechanism and clinical practice of traditional Chinese medicine intervention in insulin resistance.
Qian Li
Qian Li, Master's degree. Engaged in clinical work for more than 10 years and has rich experience in the diagnosis and treatment of diabetes and its complications, thyroid diseases, metabolic syndrome and other traditional Chinese and western medicine.