Application value of combined detection of serum IL-6, SDF-1 and CD64 in the diagnosis of early postoperative infection after limb fractures

ABSTRACT

Objective. To explore the application value of combined detection of serum interleukin-6 (IL-6), stromal cell-derived factor-1 (SDF-1) and neutrophils CD64 (CD64) in the diagnosis of early postoperative infection after limb fractures. Methods. 419 patients with limb fractures un erwent surgical treatment in our hospital were selected as study subjects, and they were divided into infection group (n = 104) and non-infection group (n = 315) according to postoperative pathological results of puncture to detect the levels of serum IL-6, SDF-1 and CD64 in the two groups on the 1st, 3rd, 5th and 7th day after surgery, and to analyze the clinical diagnostic efficacy of single and combined detection of the three indexes in early postoperative infection after limb fractures by ROC curve. Results. The levels of serum IL-6, SDF-1 and CD64 in infection group were overtly higher than those in non-infection group at different time after surgery (P < 0.05), and the AUC value, specificity and sensitivity of combined detection were higher than those of single diagnosis. In this study, 14 patients in infection group underwent reoperation, 22 patients received conservative treatment in the later period, 6 patients had postoperative muscular dystrophy, and the remaining patients had a good prognosis. Conclusion. Serum IL-6, SDF-1 and CD64 are closely related to the occurrence of early postoperative infection after limb fractures, and their combination is helpful to improve diagnostic accuracy of early postoperative infection and provide effective reference value for the treatment of postoperative infection in orthopedics.

KEYWORDS:

• Serum IL-6
• SDF-1
• CD64
• early postoperative infection after limb fractures
• diagnosis

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Additional information

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Notes on contributors

Tong Liu

Tong Liu, Master of Medicine, has rich experience in trauma and orthopedics, foot and ankle surgery, spinal surgery, and other fields. Research interests: the treatment of bone and joint trauma, the diagnosis and treatment of joint degeneration, and the correction of deformities, such as ankle arthritis, hallux valgus, flat foot, high arched foot, talipes equinovarus, heel pain, sports trauma sequelae, and minimally invasive treatment of ankle arthroscopy.

Dajiang Xin

Dajiang Xin, Master of Medicine, Deputy Director of the Third Department of Trauma, Chief Physician, Yantai Mountain Hospital. He also serves as the Vice Chairman of the Orthopedic Trauma Branch of the Shandong Rehabilitation Medical Association, a member of the Professional Committee of Foot and Ankle Medicine of the Chinese Research Hospital Association, a member of the Wound Emergency Branch of the Shandong Medical Doctor Association, and a member of the Foot and Ankle Surgery Branch of the Shandong Medical Promotion Association. Engaged in clinical work in orthopedics and trauma for over 20 years. He is skilled in the treatment of complex trauma and has rich clinical experience in minimally invasive treatment of limb fractures.