Redox signaling regulates the skeletal tissue development and regeneration

ABSTRACT

Skeletal tissue development and regeneration in mammals are intricate, multistep, and highly regulated processes. Various signaling pathways have been implicated in the regulation of these processes, including redox. Redox signaling is the signal transduction by electron transfer reactions involving free radicals or related species. Redox homeostasis is essential to cell metabolic states, as the ROS not only regulates cell biological processes but also mediates physiological processes. Following a bone fracture, redox signaling is also triggered to regulate bone healing and regeneration by targeting resident stromal cells, osteoblasts, osteoclasts and endothelial cells. This review will focus on how the redox signaling impact the bone development and bone regeneration.

KEYWORDS:

• redox signaling
• bone regeneration
• mesenchymal stem cells
• angiogenesis
• osteoblasts

Author contributions

Conceptualization, L.Z.; Writing – original draft preparation, H.Z., H.J. and H.H.; writing and editing, W.G., X.W., and H.Z. All authors read and approved the manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the by the National Natural Science Foundation of China (81673991, 81730107), the National Key Research and Development Project (2018YFC1704300), and the Program for Innovative Research Team of Ministry of Education of China (IRT1270).

Notes on contributors

Hao Zhang

Hao Zhang, PhD & Postdoctoral fellow, Postdoctoral fellow, Louisiana State University, USA, PhD, Shanghai University of Traditional Chinese Medicine, majoring in stem cell bone regeneration related research.

Jin Hao

Jin hao, Shuguang Clinical Medical College, Shanghai University of Traditional Chinese Medicine, professional master, osteoarthritis related research, junior title, resident physician.

HaiPing Hong

Haiping Hong, Master of Medicine, graduated from Shanghai University of Traditional Chinese Medicine, mainly engaged in bone and joint degenerative diseases related research.

Wei Gu

Wei Gu, Master of Medicine, graduated from Fudan University School of Medicine, Shanghai, mainly engaged in bone and joint degenerative diseases related research.

Zhiqiang Li

Zhiqiang Li, Master of Medicine, graduated from Tongji University School of Medicine, Shanghai, mainly engaged in spinal diseases related research.

Jun Sun

Jun Sun, Doctor of medicine, graduated from Shanghai Jiao Tong University, School of Medicine, mainly engaged in clinical research of joint diseases.

Xiaoen Wei

Xiaoen Wei, Doctor, graduated from Shanghai Jiao Tong University School of Medicine, mainly engaged in the related research of degenerative bone and joint diseases, specializing in the surgery and conservative treatment of various knee diseases.

Lin Zhou

Lin Zhou, Master of medicine, associate chief physician, graduated from Fudan University, Shanghai, mainly engaged in bone and joint traumatic diseases related research.