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ABSTRACT
This study aims to study the effffects of Tiaoshen Changzhi acupuncture on behavior and striatum ΔFosB in rats with Levodopa-induced Dyskinesias (LIDs). In this experimental study, Levodopa-induced Dyskinesia (LID) rat models were established by 6-OHDA double-target injection and randomly assigned to six groups, with ten rats in each group. The rats were subjected to difffferent interventions for 28 days, and their behavior was observed. Additionally, the content of ΔFosB, a marker of neuronal activation, in the rat striatum was detected by immunohistochemistry and qRT-PCR. In contrallateral rotation behavior experiment and AIM experiment, the score of the model group was significantly increased, compared with the model group, the score of the Western medicine group, the ordinary acupuncture group and the Tiaoshen Changzhi group was significantly decreased (P < 0.01), the score of the Western medicine group and the Tiaoshen Changzhi group was significantly lower than the ordinary acupuncture group (P < 0.01), there was no statistical significance between the Western medicine group and the Tiaoshen Changzhi group (P>0.05). In the left forelimb function test, the score of the model group was significantly decreased, and compared with the model group, the left forelimb function score of the Western medicine group, the ordinary acupuncture group and the Tiaoshen Changzhi group were significantly increased (P < 0.01). The left forelimb function score of the Western medicine group and the Tiaoshen Changzhi group was higher than the ordinary acupuncture group (P < 0.05, P < 0.01). There was no statistical significance between Western medicine group and Tiaoshen Changzhi group (P > 0.05). After treatment, the content of ΔFosB in the striatum of the Western medicine group, the ordinary acupuncture group and the Tiaoshen Changzhi acupuncture group all decreased, the Western medicine group was better than the ordinary acupuncture group (P < 0.01), and the Tiaoshen Changzhi acupuncture group was better than the ordinary acupuncture group (P < 0.05). Tiaoshen Changzhi acupuncture can improve the behavioral performance of LID rats, reduce abnormal involuntary movement and contralateral rotation behavior and enhance the motor function of the left forelimb of rats. One of its therapeutic mechanisms for LID may be to reduce the expression level of ΔFosB in the striatum of LID rats, thereby reducing the symptoms of LID rats.
Availability of data and materials
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Disclosure statement
No potential conflict of interest was reported by the authors.
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Notes on contributors
Yuan Li
Yuan Li, Major in acupuncture and moxibustion and Massage. The major research direction is the basic and clinical research of acupuncture and medicine combined treatment of nervous system diseases. PhD candidate in the University of Traditional Chinese Medicine.
Jiamin Zhu
Jiamin Zhu, Major in acupuncture and moxibustion and Massage. Research direction: acupuncture treatment of nervous system disease. The Sixth Ward of acupuncture and moxibustion Department of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine.
Peng Sang
Peng Sang, Major in acupuncture and moxibustion and Massage. The major research direction is the basic and clinical research of acupuncture and medicine combined treatment of nervous system diseases. The fifth Ward of acupuncture and moxibustion Department of Heilongjiang Academy of Traditional Chinese Medicine.
Yan Bai
Yan Bai, Major in acupuncture and moxibustion and Massage. The major research direction is the basic and clinical research of acupuncture and medicine combined treatment of nervous system diseases. Deputy Director of Acupuncture Research Institute of Heilongjiang Academy of Traditional Chinese Medicine.
Jinrong Lu
Jinrong Lu, Major in acupuncture and moxibustion and Massage. Works at the School of International Education, Heilongjiang University of Chinese Medicine.
Hong Sun
Hong Sun, Research direction: The combination of acupuncture and medicine with modern rehabilitation treatment scheme promotes the functional recovery of nervous system disease. The Sixth Ward of acupuncture and moxibustion Department of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine.
Shun Wang
Wang Shun, Major in acupuncture and moxibustion and Massage. Engaged in the basic and clinical research of acupuncture and medicine combined treatment of nervous system diseases. Vice President of Heilongjiang University of Chinese Medicine.