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ABSTRACT
Acute anterior uveitis (AAU) can cause great pain to patients. Th cytokines in peripheral blood are significantly changed in these patients, including serum interleukin-23 (IL-23), interleukin-17 (IL-17), interleukin-4 (IL-4), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) increase. However, the relationship between Th cytokines and recurrence of AAU is still unclear. Ninety-two cases of AAU were enrolled from January 2020 to April 2022 in our hospital (observation group). Levels of peripheral blood Th cytokines were detected, which were compared between acute and remission stages. After 6 months of follow-up, the relationships between Th cytokines in peripheral blood and recurrence in the observation group were analyzed. The prediction of Th cytokines on recurrence was analyzed. (1) The recurrence rate was 25.00%, and there were no statistical differences in the serum IL-23, IL-17, IL-4, IFN-γ, TNF-α and TGF-β 1 levels between patients with bilateral disease and unilateral disease (P < 0.05). (2) The serum IL-23, IL-17, IL-4, IFN-γ, TNF-α and TGF-β 1 levels of recurrence patients were higher than those of non-recurrence (t = 2.971, 5.357, 2.197, 2.766, 4.395, 2.983, P < 0.05). (3) The serum IL-23, IL-17, TNF-α levels were risk factors for recurrence (OR = 1.035, 1.210, 1.155, P < 0.05). (4) There were positive relationships between serum IL-23, IL-17, IL-4, IFN-γ, TNF-α and TGF-β 1 levels and recurrence (r = 0.317, 0.526, 0.248, 0.304, 0.480, 0.325, P < 0.05).
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No potential conflict of interest was reported by the authors.
Data Sharing Agreement
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Declaration of Conflicting Interests
The author(s) declared no potential conflicts of interest with respect to the research, author-ship, and/or publication of this article.
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Zhipeng Wu
Zhipeng Wu, is a master's student at Zunyi Medical University. He completed a master's degree in ophthalmology at Zunyi Medical University. His research direction is vitreoretinopathy.
Xiwu Hou
Xiwu Hou, is an undergraduate student at Zhangjiakou Medical College. He completed his bachelor's degree at Zhangjiakou Medical College. His research focuses on uveitis and vitreoretinopathy.
Tingyu Qin
Tingyu Qin, is a doctoral student at Chongqing Medical University. He completed his doctoral degree in ophthalmology at Chongqing Medical University. His research direction is vitreoretinopathy.