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Original Articles

Isolation and identification of hydroxythiohomosildenafil in herbal dietary supplements sold as sexual performance enhancement products

, , , , , , & show all
Pages 145-151 | Received 19 Jun 2008, Accepted 25 Jul 2008, Published online: 05 Feb 2009
 

Abstract

An unknown compound is detected and isolated from two herbal dietary supplements bought on the internet. The structure of the unknown compound is elucidated using ESI–MS/MS, NMR, UV and IR. The compound, named hydroxythiohomosildenafil, is identified as an analogue of sildenafil in which the oxygen atom is substituted with a sulfur atom in the pyrazolopyrimidine moiety, and a hydroxyethyl group instead of a methyl group is attached to the piperazinyl nitrogen. It is the first report of this compound being detected in herbal dietary supplements. The UV, IR and completely assigned NMR data of hydroxythiohomosildenafil is recorded.

Acknowledgements

The financial support from the National University of Singapore Academic Research Fund (KHL) and research scholarship (LL) is acknowledged.

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