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Abstract
A liquid chromatographic method for determining residues of ionophores in bovine, porcine, and avian tissues is described. Tissues were extracted with iso‐octane‐ethyl acetate and the extracts purified on silica solid‐phase extraction columns. Monensin, narasin and salinomycin were detected by UV absorbance following post‐column derivatization with vanillin, and lasalocid was detected underivatized using fluorescence. In muscle, kidney and fat, all drugs were determined from a single sample extract. In liver, a separate extraction was done to determine lasalocid. The detection limit for lasalocid, narasin and salinomycin was 5 ppb; for monensin it was 2ppb. Average recoveries were: lasalocid—71.0%; monensin—94.3%; salinomycin—97.2%; narasin—94.1 %.