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Journal of Microencapsulation
Micro and Nano Carriers
Volume 23, 2006 - Issue 3
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Research Article

Emulsification preparation of chitosan–urethane microbeads in the presence of a water-soluble blocked diisocyanate, containing furanone homosyrine lactone bacterial inhibitors

R. R. Price Center for Biomolecular Science and Engineering, Naval Research Laboratory, Washington, DC, USA
,
L. C. Passaro Center for Biomolecular Science and Engineering, Naval Research Laboratory, Washington, DC, USA
&
E. R. Welsh United States Naval Academy, Chemistry Department, Annapolis, MD, USA
Pages 259-264 | Received 07 Oct 2004, Accepted 10 Feb 2005, Published online: 08 Oct 2008
 
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Abstract

Chitosan is an abundant naturally occurring biopolymer that is biocompatible, of low toxicity and is well suited as a carrier for a range of active agents. Restrictions imposed by this biopolymers unique solubility requirements make if difficult to process. One approach to an internal setting system is to employ the water-soluble blocked isocyanate hexamethylene-1,6-di(aminocarboxysulphonate) (HDACS) in order to cross-link the chitosan and form microspheres in situ utilizing simple emulsion systems. Chitothane microspheres are capable of delivering active agents at controlled release rates and offers a viable alternative to external set methodologies utilizing aldehydes or similar cross-linking agents.

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