Advanced search
Publication Cover
Journal of Microencapsulation
Micro and Nano Carriers
Volume 25, 2008 - Issue 2
Submit an article Journal homepage
105
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug

Hwa Young Park Department of Advanced Materials, Hannam University, Yususng, Daejeon, Korea
,
Keun Sang Oh Department of Advanced Materials, Hannam University, Yususng, Daejeon, Korea
,
Hyoung Mo Koo Department of Advanced Materials, Hannam University, Yususng, Daejeon, Korea
,
Sun Hang Cho Nanobiomaterials Laboratories, Yusung, Daejeon, Korea
,
Sang Jun Chung BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusung, Daejeon, Korea
,
Yong Taik Lim BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusung, Daejeon, Korea
,
Dongmin Kim School of Electrical, Electronic and Computer Engineering, Hongik University, Jochiwon, Chungnam, Korea
&
Soon Hong Yuk Department of Advanced Materials, Hannam University, Yususng, Daejeon, Korea
 show all
Pages 106-110 | Received 07 Jun 2007, Accepted 09 Nov 2007, Published online: 08 Oct 2008
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 721.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.