Folate-decorated and NIR-activated nanoparticles based on platinum(IV) prodrugs for targeted therapy of ovarian cancer

Abstract

Platinum-based drugs are used to treat a variety of cancers but have many side effects such as nephrotoxicity and neurotoxicity. A folate-decorated nanoparticles system with a good drug payload can selectively deliver drugs into folate receptor (FR)-overexpressing cancer cells to prevent the shortcomings of platinum-based chemotherapy. Here, folate-decorated and near-infrared (NIR) laser-activated nanoparticles (abbreviated as Pt^IV-FINPs) were prepared via ultrasonic self-assembling of platinum(IV) prodrug c,c,t-Pt(NH₃)₂Cl₂(OOCCH₂CH₂COOH)₂, folic acid (FA)-functionalized lipid DSPE-PEG-FA and NIR fluorescent dye indocyanine green (ICG). The obtained Pt^IV-FINPs had almost spherical shape with a mean diameter about 100 nm. In vitro cellular uptake, cytotoxicity assays revealed that upon NIR irradiation, Pt^IV-FINPs further enhanced cellular uptake and generated higher cytotoxicity against human ovarian carcinoma SKOV3 cells than non-targeted or non-NIR activated nanoparticles. Thus, the multifunctional nanoparticles have potential to be developed as an attractive drug delivery system for effective chemotherapy against FR-overexpressing cells.

Keywords:

• Nanoparticles
• targeted drug delivery
• near-infrared irradiation
• platinum(IV) prodrugs
• ovarian cancer

Disclosure statement

The authors report no conflicts of interest.

Additional information

Funding

This work was supported by National Natural Science Foundation of China [No. 21371031], Anhui Provincial Natural Science Foundation [No. 1708085MH207], International S&T Cooperation Program of China [No. 2015DFG42240], Engineering Technology Research Center of Polysaccharides Drug of Anhui Province, Priority Academic Program Development of Jiangsu Higher Education Institutions.