Development and characterization of morin hydrate-loaded micellar nanocarriers for the effective management of Alzheimer’s disease

Abstract

The aim of this study was to prepare and characterise oral delivery of morin hydrate-loaded micellar nanocarriers using Pluronic P127 and Pluronic F123 for the effective management of Alzheimer’s disease. After administration of formulation brain and blood drug concentration were found to be highest for optimised morin hydrate-loaded micellar nanocarriers as compared to plain morin hydrate. Significant (p < 0.05) reduction in assessed pharmacodynamic parameters was observed after administration of morin hydrate-loaded micellar nanocarriers as compared to disease control group. Chronic treatment with morin-loaded micelles significantly increased the memory in AlCl₃ induced Alzheimer’s disease in Wistar rats.

Keywords:

• Alzheimer’s disease
• Blood–brain barrier
• Micelles
• Pluronic block polymers
• critical micelle concentration

Disclosure statement

No potential conflict of interest was reported by the authors.