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Original Articles

Chitosan/β-glycerophosphate-based microparticles manufactured by laminar jet break-up technology

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Pages 407-420 | Received 04 Mar 2018, Accepted 21 Aug 2018, Published online: 09 Oct 2018
 

Abstract

This study is about the use of β-glycerophosphate (βGP) to modulate the production of chitosan microparticles through a technology of jet break-up. βGP has been described as capable of producing chitosan gels without additional complexing agents via a thermal transition (inverse gelation). A preliminary assessment on the effect of temperature on the viscosity and gelation of chitosan/βGP precursors demonstrated that the crosslinking process was too slow to afford microparticle production via jet break-up. Instead, βGP was used as a solubilizer to provide stable chitosan solution at neutral pH, which allowed the preparation of microparticles through polyelectrolyte complexation (with triphosphate) under physiological conditions, as opposed to the more conventional method of chitosan solubilisation in acids. Here, the key parameters of the microencapsulation process have been optimized, aiming to produce spherical particle of well-defined size and circularity, as well as toroidal microparticles, with a physico-chemical evaluation of the products.

Disclosure statement

No potential conflict of interest was reported by the authors.

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