Novel folated pluronic F127 modified liposomes for delivery of curcumin: preparation, release, and cytotoxicity

Abstract

Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes with FA group on the surface, and evaluate the effects of FA-F127 modification on the properties of the modified liposomes.

Methods: FA was linked to one end of pluronic F127, via the terminal OH group, to obtain FA-F127 and the structure was characterised. FA-F127 modified curcumin liposomes (cur-FA-F127-Lps) were prepared. The physicochemical characteristics of cur-FA-F127-Lps, including morphology and particle size, were studied. The in vitro cytotoxicity of cur-FA-F127-Lps against KB cancer cells was determined by MTT tests.

Results: The effects of FA-F127 modification on the average particle size, PDI, curcumin encapsulation efficiency and microstructure were not significant. Compared with nonfolated F127 liposomes (cur-F127-Lps), cur-FA-F127-Lps exhibited significantly higher cytotoxicity towards KB cells.

Conclusions: Folic acid modified liposomes provide a novel strategy to improve the chemotherapeutic efficacy of hydrophobic bioactive compounds.

Keywords:

• Liposomes
• pluronic F127
• folic acid
• curcumin
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors appreciate the financial support by the National Natural Science Foundation of China [Nos. 21766008, 21766018, and 21664007], Open Project Program of State Key Laboratory of Food Science and Technology, Nanchang University [No. SKLF-KF-201822], the Doctoral Scientific Research Foundation of Jiangxi Science and Technology Normal University [No. 2019BSQD012].