Nano-lipidic formulation and therapeutic strategies for Alzheimer’s disease via intranasal route

Abstract

Aim

The inability of drug molecules to cross the ‘Blood-Brain Barrier’ restrict the effective treatment of Alzheimer’s disease. Lipid nanocarriers have proven to be a novel paradigm in brain targeting of bioactive by facilitating suitable therapeutic concentrations to be attained in the brain.

Methods

The relevant information regarding the title of this review article was collected from the peer-reviewed published articles. Also, the physicochemical properties, and their in vitro and in vivo evaluations were presented in this review article.

Results

Administration of lipid-based nano-carriers have abilities to target the brain, improve the pharmacokinetic and pharmacodynamics properties of drugs, and mitigate the side effects of encapsulated therapeutic active agents.

Conclusion

Unlike oral and other routes, the Intranasal route promises high bioavailability, low first-pass effect, better pharmacokinetic properties, bypass of the systemic circulation, fewer incidences of unwanted side effects, and direct delivery of anti-AD drugs to the brain via circumventing ‘Blood-Brain Barrier’.

Keywords:

• Alzheimer’s disease
• intranasal route
• nano-lipidic formulation

Acknowledgements

We acknowledge the Department of Pharmaceuticals (DoP), Ministry of Chemicals and Fertilizers, Government of India, for the financial support. The NIPER-R communication number for this publication is NIPER-R/Communication/190.

Disclosure statement

No potential conflict of interest was reported by the author(s).