Molecularly imprinted polymers: preparation, characterisation, and application in drug delivery systems

Abstract

Molecular imprinting technology defines the creation of molecularly imprinted polymer (MIP) molecules in which template molecules can place in a key-lock relationship through shape, diameter, and functional groups. Although molecular imprinting technology has been employed in different fields, its applications in drug delivery systems (DDSs) have gained momentum recently. The high loading efficiency, high stability, and controlled drug release are the primary advantages of MIPs. Here, the main components, preparation methods, and characterisation tests of MIPs are summarised, and their applications in DDSs administered by different routes are evaluated in detail. The review offers a perspective on molecular imprinting technology and applications of MIPs in drug delivery by surveying the literature approximately 1998–2021 together with the outlined prospects.

Keywords:

• Molecular imprinting
• polymerisation
• template
• drug delivery
• controlled/sustained release
• ophthalmic
• oral
• parenteral
• transdermal

Acknowledgements

Figures 1–3 and Supplementary Figure 2 were created with BioRender.com.

Disclosure statement

No potential conflict of interest was reported by the author(s).