Fabrication of zinc-loaded silicon carbide nanocomposite for in vitro cell viability and in vivo wound dressing care

Abstract

Aim

In this investigation, Zinc-silicon carbide (Zn-SiC) materials were fabricated by a simple approach by using Zn nanoparticles (Zn-NPs) loaded on silicon carbide (SiC) with enhanced antibacterial and healing activity.

Methods

Zn-NPs loaded on SiC fabricated by the DIY laser melting technique. The TEM and Zeta-sizer confirmed the morphology and size of the nanoparticles. The characterisation was done using Fourier transforms infra-red spectroscopy, and X-ray diffraction, thermogravimetric analysis. Further, the fabricated nanoparticles were evaluated for their mechanical properties and biocompatibility under storage conditions. In vivo wound healing was measured by observing a percentage reduction in the wound.

Results

Zn-SiC NPs have 54.6 ± 5.25 nm mean particle size, −15.9 ± 2.35 mV zeta potential with 0.187 ± 0.05 polydispersity index. The nanoparticles showed good biocompatibility and in vivo wound healing properties.

Conclusions

These results strongly support the possibility of using these Zn particles loaded on SiC NPs as a promising wound healing agent after caesarean section.

Keywords:

• Zinc
• SiC nanoparticles
• Zn-SiC composite coatings
• Zn-SiC NPs
• wound dressing

Disclosure statement

No potential conflict of interest was reported by the authors.