Abstract
Green-synthesis of biodegradable polymeric curcumin-nanoparticles using affordable biodegradable polymers to enhance curcumin’s solubility and anti-oxidative potential. The curcumin-nanoparticle was prepared based on the ionic-interaction method without using any chemical surfactants, and the particle-size, zeta-potential, surface-morphology, entrapmentefficiency, and in-vitro drug release study were used to optimise the formulation. The antioxidant activity was investigated using H2DCFDA staining in the zebrafish (Danio rerio) model. The mean-diameter of blank nanoparticles was 178.2 nm (±4.69), and that of curcuminnanoparticles was about 227.7 nm (±10.4), with a PDI value of 0.312 (±0.023) and 0.360 (±0.02). The encapsulation-efficacy was found to be 34% (±1.8), with significantly reduced oxidative-stress and toxicity (∼5 times) in the zebrafish model compared to standard curcumin. The results suggested that the current way of encapsulating curcumin using affordable, biodegradable, natural polymers could be a better approach to enhancing curcumin’s water solubility and bioactivity, which could further be translated into potential therapeutics.
Acknowledgement
The authors thank NITTE (Deemed to be University) for providing the resources and facilities to conduct the experiments. The authors also thank Central Instrument Centre, Tripura University for the instrumentation facility. We also thank the Department of pharmacy Tripura University, for their technical support.
Authors contributions
AS: Methodology, Investigation, Writing – original draft, KK: Methodology, Investigation, HM: Methodology, Writing – original draft, PS: Formal analysis, Writing – review & editing, GC: Formal analysis, Writing – review & editing, BM: Writing – review & editing, Formal analysis, AUS: Methodology, Writing – review & editing, Formal analysis, AC: Conceptualisation, Supervision, Writing – review & editing, SKS: Conceptualisation, Supervision, Writing – review & editing.
Disclosure statement
No potential conflict of interest was reported by the authors.
Data availability statement
All the data thus generated for these research works are included in the manuscript.