Pre-clinical evaluation of a two-channel microwave hyperthermia system with adaptive phase control in a large animal

Abstract

A pre-clinical assessment of the heating capabilities of a two-channel 915MHz Microfocus-1000 hyperthermia system, with adaptive phase control, was carried out in a series of experiments using a large animal model. The results of the experimental measurements of specific absorption rate (SAR) and tissue temperature show that when muscle tissue of the hind legs of pigs was compressed to 6.5-7cm, then a pair of parallel opposed, coherently driven, transverse electromagnetic wave applicators could elevate the temperature in deep tissue to therapeutic levels without overheating superficial tissues when the phase difference between applicators was determined by the adaptive phase control algorithm.

• Hyperthermia;Microwave;Adaptive Phase Control;Breast Tumours