Flexible objective Bayesian linear regression with applications in survival analysis

ABSTRACT

We study objective Bayesian inference for linear regression models with residual errors distributed according to the class of two-piece scale mixtures of normal distributions. These models allow for capturing departures from the usual assumption of normality of the errors in terms of heavy tails, asymmetry, and certain types of heteroscedasticity. We propose a general non-informative, scale-invariant, prior structure and provide sufficient conditions for the propriety of the posterior distribution of the model parameters, which cover cases when the response variables are censored. These results allow us to apply the proposed models in the context of survival analysis. This paper represents an extension to the Bayesian framework of the models proposed in [16]. We present a simulation study that shows good frequentist properties of the posterior credible intervals as well as point estimators associated to the proposed priors. We illustrate the performance of these models with real data in the context of survival analysis of cancer patients.

KEYWORDS:

• Accelerated failure time model
• residual life
• non-informative prior
• predictive
• two-piecedistributions

AMS SUBJECT CLASSIFICATION:

• 62E15
• 62N01
• 62N02
• 62P10

Disclosure statement

No potential conflict of interest was reported by the authors.