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Abstract
The present work proposes a preparation method for multilayered Au nanoparticle/silica/gadolinium compound core–shell (Au/SiO2/GdC) particles. Silica-coated Au core–shell (Au/SiO2) particles with a size of 38.0 nm were prepared by a sol-gel reaction in the presence of the Au nanoparticles with a size of 15.5 nm. Multilayered Au/SiO2/GdC particles with sizes of ca. 35–52 nm were prepared by a homogeneous precipitation reaction in the presence of Au/SiO2 particles. The computed tomography (CT) value of the Au/SiO2/GdC colloid solution containing 4.3 × 10−2 M Au was 344.1 HU: Its converted CT value (CT divided by Au concentration) was as large as 8.0 × 103 HU/M. The r1 value of the Au/SiO2/GdC colloid solution was as large as 3.5 mM−1 s−1.
Acknowledgements
We express our thanks to Professor T. Noguchi at the College of Science of Ibaraki University, Japan (current affiliation: Faculty of Arts and Science of Kyushu University, Japan), for his help with the TEM observation. This study was supported by a Grant-in-Aid for Scientific Research on Innovative Areas ‘Nanomedicine Molecular Science’ (No. 2306) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, by JSPS KAKENHI Grant Number 24310085, and by A3 Foresight Program from JSPS.