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British Journal of Neurosurgery Volume 22, 2008 - Issue sup1: Proceedings from Pedunculopontine Nucleus Meeting
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Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford

E. A. Pereira Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital; Nuffield Department of Surgery, University of Oxford, Oxford, UK
,
K. A. Muthusamy Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital; Nuffield Department of Surgery, University of Oxford, Oxford, UK
,
N. De Pennington Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital; Nuffield Department of Surgery, University of Oxford, Oxford, UK
,
C. A. Joint Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital; Nuffield Department of Surgery, University of Oxford, Oxford, UK
&
Professor T. Z. Aziz Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital; Nuffield Department of Surgery, University of Oxford, Oxford, UKCorrespondence[email protected]
Pages S41-S44 | Received 27 May 2008, Accepted 01 Jun 2008, Published online: 06 Jul 2009
 
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Abstract

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here, we summarize our non-human primate and neuroimaging research of relevance to our surgical targeting of the PPN. We also describe our clinical experience of PPN DBS with greatest motor improvements achieved by stimulation at low frequencies.

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