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Disclosure statement
HH has received research monies and a consultancy fee from Astellas (Ireland) and Pfizer (Ireland) during the last four years, but not in areas related to the contents of this manuscript. BD, SMcN and MJ have no conflicts of interest to declare.
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Funding
The collation of material and the drafting of this manuscript was not supported by external funding but was undertaken during routine clinical and academic activities.