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Brain Injury Volume 31, 2017 - Issue 10
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Articles

Diffusion imaging of mild traumatic brain injury in the impact accelerated rodent model: A pilot study

Zora KikinisPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USACorrespondence[email protected]
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Marc MuehlmannPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany
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Ofer PasternakPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
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Sharon PeledDepartment of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
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Praveen KulkarniCenter for Translational NeuroImaging, Department of Psychology, Northeastern University, Boston, MA, USA
,
Craig FerrisCenter for Translational NeuroImaging, Department of Psychology, Northeastern University, Boston, MA, USA
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Sylvain BouixPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
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Yogesh RathiPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
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Inga K. KoertePsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany
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Steve PieperIsomics, Inc., Cambridge, MA, USA
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Alexander YarmarkovichIsomics, Inc., Cambridge, MA, USA
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Caryn L. PorterDepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
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Bruce S. KristalDepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
&
Martha E. ShentonPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA
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Pages 1376-1381 | Received 09 Sep 2015, Accepted 07 Apr 2017, Published online: 19 Jun 2017
 
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ABSTRACT

Primary Objective: There is a need to understand pathologic processes of the brain following mild traumatic brain injury (mTBI). Previous studies report axonal injury and oedema in the first week after injury in a rodent model. This study aims to investigate the processes occurring 1 week after injury at the time of regeneration and degeneration using diffusion tensor imaging (DTI) in the impact acceleration rat mTBI model.

Research Design: Eighteen rats were subjected to impact acceleration injury, and three rats served as sham controls. Seven days post injury, DTI was acquired from fixed rat brains using a 7T scanner. Group comparison of Fractional Anisotropy (FA) values between traumatized and sham animals was performed using Tract-Based Spatial Statistics (TBSS), a method that we adapted for rats.

Main Outcomes and Results: TBSS revealed white matter regions of the brain with increased FA values in the traumatized versus sham rats, localized mainly to the contrecoup region. Regions of increased FA included the pyramidal tract, the cerebral peduncle, the superior cerebellar peduncle and to a lesser extent the fibre tracts of the corpus callosum, the anterior commissure, the fimbria of the hippocampus, the fornix, the medial forebrain bundle and the optic chiasm.

Conclusion: Seven days post injury, during the period of tissue reparation in the impact acceleration rat model of mTBI, microstructural changes to white matter can be detected using DTI.

Declaration of interest

The authors report no conflict of interest.

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