Effect of integrin AV and B8 gene polymorphisms in patients with traumatic brain injury

ABSTRACT

Background: Α few genetic variants are associated with the outcome after traumatic brain injury (TBI). Integrins are glycoprotein receptors that play an important role in the integrity of microvasculature of the brain.

Objective: To examine the role of integrin-AV (ITGAV) and integrin-B8 (ITGB8) tag single nucleotide polymorphisms (SNPs) on the outcome of patients with TBI.

Methods: 363 participants were included and genotyped for 11 SNPs for ITGAV and 11 for ITGB8 gene. SNPs were tested for associations with the 6-month outcome after TBI, the presence of a hemorrhagic event after TBI, and the initial TBI severity after adjustment for TBI’s main predictors.

Results: The ITGAV rs3911239 CC and rs7596996 GG genotypes were associated with an unfavorable outcome after TBI, compared to the TT and AA genotypes, respectively. The ITGB8 rs10239099 CC and rs3757727 CC genotypes were associated with increased risk of any cerebral hemorrhagic event after TBI compared to GG and TT respectively. The ITGAV rs7589470 and rs7565633 were associated with the TBI’s initial severity.

Conclusions: ITGAV gene SNPs may be implicated in the outcome after TBI, as well as in the initial TBI severity, and also of ITGB8 gene SNPs in the risk of hemorrhagic event after a TBI.

KEYWORDS:

• Integrins
• ITGAV
• ITGB8
• traumatic brain injury
• polymorphism
• tag SNPs

Acknowledgments

We would like to thank Georgios F. Hadjigeorgiou and Georgios Sakoutis, for their assistance, support and suggestions throughout the conduct of the work.

Declaration of interest

The authors report no conflict of interest.

Supplementary Material

Supplemental data for this article can be accessed here.

Additional information

Funding

This work was supported by the This study was supported in part by a research grant from the Research Committee of the University of Thessaly, Greece (code: 5287).

Notes on contributors

Efthimios Dardiotis

Efthimios Dardiotis,  Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.

Vasileios Siokas

Vasileios Siokas, Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.

Athina-Maria Aloizou

Athina-Maria Aloizou, Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.

Emmanouil Karampinis

Emmanouil Karampinis, Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.

Alexandros G. Brotis

Alexandros G. Brotis, Department of Neurosurgery, University of Thessaly, University Hospital of Larissa, Larissa, Greece.

Savas Grigoriadis

Savas Grigoriadis, Second Department of Neurosurgery, Hippokration University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Konstantinos Paterakis

Konstantinos Paterakis, Department of Neurosurgery, University of Thessaly, University Hospital of Larissa, Larissa, Greece.

Maria Dardioti

Maria Dardioti, Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.

Apostolos Komnos

Apostolos Komnos, Intensive Care Unit, General Hospital of Larissa, Larissa, Greece.

Eftychia Kapsalaki

Eftychia Kapsalaki, Department of Radiology, University of Thessaly, School of Medicine, Larissa, Greece.

Kostas Fountas

Kostas Fountas, Department of Neurosurgery, University of Thessaly, University Hospital of Larissa, Larissa, Greece.

Georgios M. Hadjigeorgiou

Georgios M. Hadjigeorgiou, Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.