The influence of intracranial hypertension on static cerebral autoregulation

ABSTRACT

Objectives

To analyze the influences of mild and severe intracranial hypertension on cerebral autoregulation (CA).

Patients and Methods

Duroc piglets were monitored with an intracranial pressure (ICP) catheter. Intracranial hypertension was induced via infusion of 4 or 7 ml of saline solution by a bladder catheter that was inserted into the parietal lobe. The static cerebral autoregulation (sCA) index was evaluated via cerebral blood flow velocities (CBFv). Piglets with ICPs ≤ 25 and > 25 mmHg were considered as group 1 and 2, respectively. Continuous variables were evaluated using the Kolmogorov-Smirnov goodness-of-fit test. The main parameters were collected before and after ICH induction and compared using two-factor mixed-design ANOVAs with the factor of experimental group (mild and severe ICH).

Results

In group 1 (ICP ≤ 25 mmHg), there were significant differences in sCA (p = .01) and ICP (p = .0002) between the basal and balloon inflation conditions. In group 2 (ICP > 25 mmHg), there were significant differences in CBFv (p = .0072), the sCA index (p = .0001) and ICP (p = .00001) between the basal and balloon inflation conditions.

Conclusion

We conclude that intracranial hypertension may have a direct effect on sCA

KEYWORDS:

• Mild intracranial hypertension
• cerebral autoregulation
• intracranial hypertension
• experimental model

Acknowledgments

Not applicable.

Availability of data and materials

The datasets used and/or analysed in the current study are available from the corresponding author upon reasonable request.

Competing interests

The authors declare that they have no competing interests.

Conflicts of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria, educational grants, participation in speakers’ bureaus, memberships, employment, consultancies, stock ownership, or other equity interests, or expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo provided financial support in the form of grant funding. The sponsor had no role in the design or conduct of this research