Abstract
This study examined differential impact of the valence and arousal characteristics of stimuli on memory biases and brain activity in major depressive disorder (MDD) and non-depressed control participants. P300 and slow wave (SW) components of the event-related brain potential (ERP) were recorded in 18 MDD and 18 control individuals during the encoding of positive and negative, high and low arousal words in a free recall task. Control participants demonstrated expected enhanced memory for positive stimuli that was accompanied by a corresponding increase in SW ERP components. These effects were not seen in the MDD participants. Rather, memory biases for negative information in MDD were only observed for low arousal words and were not reflected in ERP amplitudes. This study suggests that the inconsistency in the MDD memory bias literature may be related to the arousing nature of the stimuli incorporated in the study.
Acknowledgements
This research was supported by National Institute of Mental Health B START Grant 1R03M H57694–01 as well as Harvard College Research Program grants.
We would like to thank Chiau-Fang Chen for her data analysis assistance. There are no conflicts of interest (financial or otherwise) related to this work.
Notes
1 The main ANOVAs for P300, SW1, and SW2 yielded a number of significant effects that were not central to the main focus of the paper and, therefore, are not presented in the text.