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Current Eye Research Volume 33, 2008 - Issue 2
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Research Article

Dorzolamide/Timolol Fixed Combination Versus Latanoprost/Timolol Fixed Combination in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension

Barbara Cvenkel University Eye Clinic Ljubljana, Ljubljana, Slovenia
,
Jeanette A. Stewart PRN Pharmaceutical Research Network, LLC, Dallas, Texas, USA
,
Lindsay A. Nelson Charleston Research Company, LLC, Charleston, South Carolina, USA
&
William C. Stewart PRN Pharmaceutical Research Network, LLC, Dallas, Texas, USA; Carolina Eye Institute, University of South Carolina, School of Medicine, Columbia, South Carolina, USA
Pages 163-168 | Received 19 Oct 2007, Accepted 21 Nov 2007, Published online: 02 Jul 2009
 
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Abstract

Purpose: The efficacy of dorzolamide/timolol fixed combination (DTFC) versus latanoprost/timolol fixed combination (LTFC) in open-angle glaucoma or ocular hypertensive patients. Methods: Patients were randomized to DTFC or LTFC for 6 weeks and switched to opposite treatment for Period 2. Results: Thirty-two completed patients had a mean diurnal IOP of 19.5 ± 3.2 mmHg for DTFC and 18.9 ± 3.4 mmHg for LTFC (p = 0.12), with no significant difference found between DTFC and LTFC at any timepoint following a Bonferroni correction (p ≥ 0.01). Conclusions: Patients treated with DTFC and LTFC have a statistically similar ocular hypotensive effect.

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