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Current Eye Research Volume 33, 2008 - Issue 2
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Research Article

Expression of COX-2 and Prognostic Outcome in Uveal Melanoma

Lorna M. Cryan School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
,
Luminita Paraoan School of Clinical Sciences, Unit of Ophthalmology, University of Liverpool, Liverpool, United Kingdom
,
Paul Hiscott School of Clinical Sciences, Unit of Ophthalmology, University of Liverpool, Liverpool, United Kingdom
,
Bertil E. Damato St Pauls Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom
,
Ian Grierson School of Clinical Sciences, Unit of Ophthalmology, University of Liverpool, Liverpool, United Kingdom
,
Donna Gray School of Clinical Sciences, Unit of Ophthalmology, University of Liverpool, Liverpool, United Kingdom
,
Michael Farrell Department of Neuroscience, Beaumont Hospital, RCSI, Dublin, Ireland
,
Glen A. Doherty School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
,
Desmond J. Fitzgerald School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
&
Colm O'Brien School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland; Department of Ophthalmology, Mater Misericordiae Hospital, Dublin, Ireland
 show all
Pages 177-184 | Received 23 Oct 2007, Accepted 13 Dec 2007, Published online: 02 Jul 2009
 
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Abstract

Purpose: The expression of cyclooxygenase-2 (COX-2) and its prognostic value in uveal melanoma was examined. Methods: Paraffin-embedded sections from 32 clinicopathologically well-characterized cases of primary uveal melanoma were immunohistochemically stained for COX-2. COX-2 expression was evaluated in terms of both the intensity and the extent of staining for each tumor. A COX-2 score encompassing both intensity and extent was also calculated for each specimen. Results: 29 specimens (90.6%) contained moderate or intense positive immunoreactivity for COX-2. A statistically significant association (p < 0.05) between COX-2 expression (intensity and score) and metastatic death was established. Conclusion: Upregulation of COX-2 expression appears to be associated with poor prognosis in uveal melanoma.

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