Comparison between Stereo Angiographic Findings and Histopathologic Findings in Endotoxin-Induced Uveitis

Abstract

Purpose: To carry out a three-dimensional analysis of uveitis using stereo angiography. Materials and Methods: Endotoxin-induced uveitis was induced by injecting lipopolysaccharide into the rat footpad, and the findings of stereo angiography with a scanning laser ophthalmoscope were compared to histopathologic results. Results: On day 2, multiple hyperfluorescent spots were observed by indocyanine green stereo angiography, which appeared to be in the superficial layer of the retina. Histopathologic findings showed infiltration of leukocytes into the corresponding area, which was the retinal nerve fiber layer. Conclusions: Stereo angiography was considered useful for three-dimensional analysis of uveitis lesions in the retina and choroid.

Keywords:

• endotoxin
• histopathology
• retina
• stereo angiography
• uveitis