361
Views
36
CrossRef citations to date
0
Altmetric
Retina/Choroid

Choroidal Thickness in Patients with Graves’ Ophthalmopathy

, &
Pages 484-490 | Received 23 Feb 2016, Accepted 25 May 2016, Published online: 15 Jul 2016
 

ABSTRACT

Purpose: The purpose of the study is to compare choroidal thickness (CT) in patients with active and inactive Graves’ ophthalmopathy (GO) and that in healthy subjects by using spectral domain optical coherence tomography (SD-OCT).

Methods: We conducted an observational, cross-sectional study of 28, 48, and 74 eyes of 14 patients with active GO (group 1), 24 patients with inactive GO (group 2), and 37 age-matched healthy subjects (group 3), respectively. Activity of GO was assessed by using initial clinical activity score (CAS). CT was measured by using SD-OCT. The differences in CT among the groups were compared, and the factors affecting subfoveal CT were analyzed.

Results: The mean subfoveal CT was significantly greater in group 1 (395.84 ± 9.68 µm) than that in group 2 and group 3 (319.76 ± 7.07 µm and 314.22 ± 5.74 µm, respectively; p < 0.001) after adjusting for age, axial length, and intraocular pressure (IOP). Subfoveal CT was positively correlated with CAS (p < 0.001; r = 0.567). In multivariate analysis, thicker subfoveal CT was associated with younger age (p < 0.001; correlation coefficient B, −1.67; 95% CI, −2.57 to −0.78); disease activity (p < 0.001; correlation coefficient B, 95.28; 95% CI, 73.14–117.43); and lower IOP ((p < 0.001; correlation coefficient B, −4.09; 95% CI, −8.03 to −0.15).

Conclusions: To our knowledge, this is the first study showing that the mean subfoveal CT increases in patients with active GO. Subfoveal CT may be a useful parameter to monitor disease activity.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 555.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.