ABSTRACT
Purpose: To investigate the associations between endothelin-1 (ET-1) and macrophage chemoattractant protein-1 (MCP-1) levels and visual field (VF) progression in normal-tension glaucoma (NTG).
Methods: We conducted a prospective, longitudinal study in 71 patients with NTG. Blood samples from all subjects were assayed for ET-1 and MCP-1 concentrations, and baseline ophthalmic examinations, including the VF, were performed. Baseline data were compared with follow-up data over 3 years.
Results: After 3 years of follow-up, 14 of the 71 patients showed VF progression, and the systemic MCP-1 level was significantly associated with VF progression (r = 0.318, p = 0.007). Multiple regression analysis showed that VF progression was significantly associated with MCP-1 (odds ratio, OR = 1.021, 95% CI = 1.003–1.040; p = 0.020) and optic disc hemorrhage (ODH; OR = 1.573; 95% CI = 1.140–2.170; p = 0.023).
Conclusions: Systemic MCP-1 levels were associated with VF progression in patients with NTG.
Declaration of interest
The authors report no conflict of interests. The authors alone are responsible for the content and writing of the paper.