ABSTRACT
Purpose: To evaluate the clinical efficacy of Lumenis® M22TM intense pulsed light (IPL) in reduction of ocular Demodex infestation in eyelashes in a prospective study.
Methods: Forty patients with ocular demodicosis were recruited. Then half were randomly picked to receive the IPL treatment, while the other half got 5% tea tree oil (as the control group). Demodex counts, the ocular surface disease index (OSDI) score, lid margin abnormalities, conjunctival congestion, tear break-up time (TBUT), corneal staining with fluorescein, meibomian gland (MG) expressibility, meibum quality, modified Schirmer I test with anaesthetic (SIT), were assessed on the day before treatment and after treatment of 30 and 90 days, respectively. Changes in the parameters were compared between the IPL group and the control group on the days after treatment of 30 and 90 days.
Results: No differences were observed in Demodex counts, lid margin abnormalities, conjunctival congestion, corneal staining with fluorescein, MG expressibility, SIT in the two groups on the days after treatment of 30 and 90 days (p > 0.05), whereas there was a statistically significant difference in the OSDI score, TBUT, meibum quality (p < 0.05). The Demodex eradication rate was more thorough in the IPL group (100%) than in the control group (75%).
Conclusions: IPL shows the preferably therapeutic potential for ocular Demodicosis.
Abbreviations
Intense pulsed light | = | IPL |
Tear break-up time | = | TBUT |
Meibomian gland | = | MG |
Ocular surface disease index | = | OSDI |
In vivo confocal microscopy | = | IVCM |
Tea tree oil | = | TTO |
Eye, Ear, Nose, and Throat | = | EENT |
Corneal fluorescein staining | = | CFS |
Schirmer I test | = | SIT |
Cylindrical dandruff | = | CD |
Light microscopic examination | = | LME |
Institute for Eye Research | = | IER |
Acknowledgments
The authors wish to thank Naiqing Zhao of the Department of Biostatistics, School of Public Health at Fudan University for assistance with the statistical analyses in this study.
Declarations
This study was conducted in compliance with the Declaration of Helsinki for research involving human participants and was approved by the Ethics Committee of the Eye, Ear, Nose, and Throat (EENT) Hospital of Fudan University. Written informed consent was obtained from all participants before the examination.
Consent for publication
Written informed consent to publish was obtained from all participants before the examination.
Availability of data and material
The main data of our study presented in the tables of the main paper
Competing interests
The authors declare that they have no competing interests
Authors’ contributions
The manuscript was written through contributions of all authors. All authors read and approved the final version of the manuscript