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Cornea & Conjunctiva

Characterization of an Electronic Corneal Prosthesis System

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Pages 914-920 | Received 13 Aug 2019, Accepted 09 Dec 2019, Published online: 03 Jan 2020
 

ABSTRACT

Purpose

Corneal opacity is a leading cause of reversible blindness worldwide. An electronic corneal prosthesis, or intraocular projector, could potentially restore high-quality vision without need for corneal clarity.

Materials and Methods

Four intraocular projection systems were constructed from commercially available electronic components and encased in biocompatible plastic housing. They were tested for optical properties, biocompatibility, heat dissipation, waterproofing, and accelerated wear. A surgical implantation technique was developed.

Results

Intraocular projectors were produced of a size that can fit within the eye. Their optics produce better than 20/200 equivalent visual acuity. MTT assay demonstrated no cytotoxicity of devices in vitro. Temperature testing demonstrated less than 2°C increase in temperature after 1 h. Three devices lasted over 12 weeks under accelerated wear conditions. Implantation surgery was demonstrated via corneal trephination insertion in a cadaver eye.

Conclusion

This is the first study to demonstrate and characterize fully functional intraocular projection systems. This technology has the potential to be an important new tool in the treatment of intractable corneal blindness.

Acknowledgements

National Eye Institute/NIH K08EY027459 (CY), P30EY001792 (MR). Department of Defense VR180058 (CY). Research to Prevent Blindness.

Conflict of interest

Authors Shim, Gong, Rosenblatt and Yu have intellectual property interest.

Additional information

Funding

United States National Eye Institute K08EY027459 (CY), P30EY001792 (MR), United States Department of Defense VR180058 (CY), Research to Prevent Blindness.

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