Correlation Between Lens Density Measured by Swept-Source Optical Coherence Tomography and Phacodynamic Parameters of Centurion Phacoemulsification

Abstract

Purpose

To evaluate the correlation between lens density measured by IOL-Master 700 based on swept-source optical coherence tomography (SS-OCT) technology and the phacodynamic parameters of Centurion phacoemulsification in cataract surgery.

Methods

This prospective study included 66 patients (83 eyes) with age-related cataracts. Using the Lens Opacities Classification System III (LOCS III), the lens nuclear color (NC), lens nuclear opalescence (NO), cortical (C), and posterior subcapsular (P) opacities were obtained. Six meridian orientations of IOL-Master 700 images were captured, and the lens and nuclear regions were analyzed using ImageJ to generate the average lens nucleus density (AND) and average lens density (ALD). Phacodynamic parameters were recorded. The correlation between lens density and the phacodynamic parameters was analyzed. According to the AND, patients were divided into four groups (soft, medium-hard, hard, and extremely hard nucleus), and the phacodynamic parameters were compared among groups.

Results

The correlation between the AND obtained by LOCS III grading and SS-OCT-based cataract quantification system score (NC and NO) was statistically significant (r_NC = 0.795, r_NO=0.794, both p = .000). AND correlated significantly with cumulative dissipated energy (CDE, r = 0.545, p = .000), total ultrasound time (TUST, r = 0.354, p = .001), and total torsional ultrasound time (TTUT, r = 0.314, p = .004). Among the four groups divided by AND, the difference in CDE (P₁₃ = 0.002, P₁₄ < 0.001, P₂₄ = 0.002) was statistically significant.

Conclusion

AND measured by IOL-Master 700, SS-OCT correlated significantly with LOCS III classification and phacodynamic parameters of the Centurion system, especially with CDE, TUST, and TTUT. AND can be used as an indicator for quantitative evaluation and help inform the surgical plan.

Keywords:

• Swept source-optical coherence tomography
• lens nucleus density
• centurion vision system
• phacodynamic parameters
• cataracts

Acknowledgements

The authors express their gratitude to the department of cataracts of Eye Hospital of Wenzhou Medical University Hangzhou Branch for their cooperation and assistance.

Authors’ contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by [XEW], [LLC] and [ZLL]. The first draft of the manuscript was written by [XEW] and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Ethical approval

The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board of Eye Hospital of Wenzhou Medical University (protocol code 2021-134-K-113-01). Informed consent was obtained from all subjects.

Consent form

All authors agree with the publication.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Additional information

Funding

This work was supported by the Zhejiang Medical Health Science and Technology Project under Grant [2023KY913]; the Natural Science Foundation of Zhejiang Province under Grant [LQ20H120002]; the "Pioneer" and "Leading Goose" R&D Program of Zhejiang under Grant [2022C03070]; the Provincial Construction Project of Zhejiang under Grant [WKJ-ZJ-2135]; the Zhejiang Provincial Program of China for the Cultivation of Health Leading Talents (Y.E.Z.), and the Wenzhou Basic Medical Health Science and Technology Project under Grant [Y20220145].