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Journal of Asthma Volume 44, 2007 - Issue 7
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ORIGINAL ARTICLE

Changes in Serum Eosinophil Cationic Protein Levels after Exercise Challenge in Asthmatic Children

Chia-Chang Hsieh First Department of Internal Medicine, School of Medicine, Kyorin University, Tokyo, Japan; Department of Pediatrics, China Medical University Hospital; Jen-Te Junior College of Medicine, Nursing and Management, Miaoli, Taiwan, R.O.C.; School of Medicine, China Medical University, Taichung, Taiwan, R.O.C.
, M.D.,
Hajime Goto First Department of Internal Medicine, School of Medicine, Kyorin University, Tokyo, Japan
, M.D.,
Hiroyuki Kobayashi First Department of Internal Medicine, School of Medicine, Kyorin University, Tokyo, Japan
, M.D.,
Wen-Chi Chow Department of Pediatrics, China Medical University Hospital; School of Medicine, China Medical University, Taichung, Taiwan, R.O.C.
, M.A.,
Wen-Huang Peng Institute of Chinese Pharmaceutical Sciences, China Medical University, 91, Hsueh-Shih Road, Taichung, Taiwan, R.O.C.
, Ph.D &
Ren-Bin Tang Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan, R.O.C.
, M.D.
Pages 569-573 | Published online: 02 Jul 2009
 
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Abstract

The aim of the present study was to assess the relationship between serum eosinophil cationic protein levels and the severity of exercise-induced bronchoconstriction in asthmatic children. The 48 asthmatic children were divided into exercise-induced bronchoconstriction group and non-exercise-induced bronchoconstriction group. In the exercise-induced bronchoconstriction group, the post-exercise serum eosinophil cationic protein levels were significantly increased as compared with the pre-exercise serum eosinophil cationic protein levels. These results suggested that eosinophil cationic protein may serve as a possible contributor to the pathophysiology of exercise-induced bronchoconstriction in asthmatic children.

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