Association of obesity with severity outcomes in hospitalized pediatric asthma exacerbations

Abstract

Introduction

While there seems to be an association between obesity and asthma, the exact nature of the relationship remains unknown. It is unclear if there is increased severity of exacerbation for those that require hospitalization. We examine the association between obesity and severity outcomes such as hospital length of stay, intensive care admissions, and need for continuous albuterol or magnesium administration.

Methods

Patients 4 to 17 years old admitted between 1/1/2012–1/1/2016 with asthma identified by discharge codes were reviewed. Obesity was defined as BMI ≥95%. Clinical data such as age, gender, family history of asthma, use of controller medication along with outcome data such as length of stay, ICU admission, use of continuous albuterol, and use of magnesium were collected. Binary outcomes were analyzed with multivariate logistic regression while length of stay was analyzed with negative binomial regression.

Results

Overall, 995 patients met inclusion criteria. The median age was 7 years old with 170 (17%) patients categorized as obese. We find no difference in length of stay (IRR 0.99 [0.91, 1.09], p = 0.9), PICU admission (OR 0.72 [0.43, 1.21], p = 0.22), or magnesium administration (OR 1.34 [0.95, 1.88], p = 0.09) between obese and non-obese patients. There were increased odds of continuous albuterol use (OR 1.47 [1.02, 2.11]) for obese patients.

Conclusion

We find no association between obesity and outcomes of length of stay, ICU admission, or magnesium administration. While growing evidence links obesity with asthma, our study suggests it may not be associated with the severity of exacerbation.

KEYWORDS:

• Pediatric obesity
• hospitalized asthma
• asthma severity

Acknowledgments

The authors would like to acknowledge Dr. Alonso Marron, Dr. Tiffany Blankenship, Morgan McCormick, Brandilyn Monene, and Greg Zhang for their help in data collection.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.