Effects of high intensity interval training on cardiorespiratory fitness and salivary levels of IL-8, IL-1ra, and IP-10 in adults with asthma and non-asthma controls

Abstract

Objective

The purpose of this study was to determine whether high intensity interval training (HIIT) would lead to improvements in 1) maximal VO₂, V_E, V_E/VCO₂, and V_E/MVV, and/or 2) resting salivary concentrations of pro-inflammatory markers Interleukin (IL-8), interferon-gamma-inducible-protein (CXCL10/IP-10)) and anti-inflammatory marker IL-1 receptor antagonist (IL-1ra) in adults with well-controlled asthma compared to non-asthma controls.

Methods

Participants completed a maximal exercise test at the beginning (T1) and end (T2) of a 6-week HIIT intervention; saliva samples were obtained at the beginning and 30 min following the first (T1) and last (T2) exercise session.

Results

Adults with asthma (n = 20; age: 21.4 ± 2.4 years) and non-asthma controls (n = 12; age: 22.5 ± 3.4 years) completed the intervention. VO₂max increased from T1 to T2 in both groups (asthma T1 32.9 ± 8, T2 38.6 ± 8.2 ml/kg/min; controls T1 34.5 ± 11.8, T2 38.9 ± 12.3 ml/kg/min). V_Emax also increased in both groups (asthma T1 97.7, T2 110.8 units, p < 0.001, h_p² = <0.04; control T1 106.3, T2 118.1, p < 0.001, h_p² 0.02). An increase in V_E/VCO₂ (F(1, 10)=22.11, p = 0.001) and V_E/MVV (F(1, 10) = 111.30, p < 0.001) was observed in the control group; no differences were observed in the asthma group. No differences in IL-8 or IL-1ra were observed between groups. In the asthma group, resting salivary IP-10 concentrations significantly decreased from T1 (0.025 pg/ug protein) to T2 (0.015 pg/ug protein, p = 0.039, h_p² = 0.3 (moderate effect)).

Conclusion

A 6-week HIIT intervention led to a similar increase in VO₂max and V_Emax in those with and without asthma, and a decrease in resting salivary IP-10 levels among adults with asthma.

Keywords:

• Asthma
• high intensity interval training
• exercise induced bronchoconstriction

Funding

The author(s) reported there is no funding associated with the work featured in this article.