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Journal of Asthma Volume 59, 2022 - Issue 12
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Pharmacotherapy

Manifesto on inhaled triple therapy in asthma: an Interasma (Global Asthma Association – GAA) document

Fulvio Braidoa IRCCS, Ospedale Policlinico San Martino, Genova, Italy;b Department of Internal Medicine, University of Genoa, Genova, ItalyORCID Iconhttps://orcid.org/0000-0003-2460-4709
, MDORCID Icon,
Angelica Tiotiuc Department of Pulmonology, University Hospital of Nancy, Nancy, France;d EA 3450 DevAH - Development, Adaptation and Disadvantage, Cardiorespiratory Regulations and Motor Control, University of Lorraine, Nancy, FranceORCID Iconhttps://orcid.org/0000-0002-8038-9559
, MD, PhDORCID Icon,
Guillermo Guidos-Fogelbache Instituto Politécnico Nacional, E.N.M.H/S.E.P.I, Laboratorio de Bioquímica Estructural, Ciudad de México, MéxicoCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1675-3894
, MD, PhD(c)ORCID Icon,
Ilaria Baiardinib Department of Internal Medicine, University of Genoa, Genova, Italy;f Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy;g IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
, MD,
Filippo Cosinih University of Genoa, Genova, Italy
, MD,
Jaime Correia de Sousai Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal;j ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
, MD, PhD,
Andras Bikovk Manchester University NHS Foundation Trust, Manchester, UK;l Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK
, MD, PhD,
Sylvia Novakovam Allergy Unit of Internal Consulting Department, University Hospital "St. George", Plovdiv, Bulgaria
, MD, PhD,
Marina Laborn Värnamo Hospital, Värnamo, SwedenORCID Iconhttps://orcid.org/0000-0001-5216-8129
, MDORCID Icon,
Igor Kaidashevo Ukrainian Medical Stomatological Academy, Poltava, Ukraine
, MD,
Denislava Nedevap Medical University Sofia, Sofia, Bulgaria
, MD, PhD,
Krzysztof Kowalq Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
, MD, PhD,
Stefan Mihaicutar Pulmonology Department, Cardio Prevent Foundation, University of Medicine and Pharmacy “Dr Victor Babes”, Timisoara, Romania
, MD, PhD,
Marilyn Urrutia Pereiras Federal University of Pampa - Campus Uruguaiana, Pediatic Program of Asthma Prevention (PIPA), Pontifícia Universidade Católica do Rio Grande do Sul, Universidad Nacional de Córdoba, Córdoba, Argentina
, MD,
Dirceu Solét Associação Brasileira de Alergia e Imunologia, Sociedade Brasileira de Pediatria, Universidade Federal de São Paulo, São Paulo, Brazil
, MD,
Plamela Novakovau Clinic of Clinical Allergy, Medical University, Sofia, Bulgaria
, MD,
Herberto Chong-Netov Division of Allergy and Immunology, Department of Pediatrics, Federal University of Paraná, Curitiba, Brazil
, MD, PhD,
Laura Vrzyh University of Genoa, Genova, Italy
, MD,
Ignacio J. Ansoteguiw Hospital Quirónsalud Bizkaia, Bilbao, Spain
, MD, PhD,
Jonathan A. Bernsteinx Division of Immunology, Department of Internal Medicine, Allergy Section University of Cincinnati, Cincinnati, OH, USA
, MD,
Louis-Philippe Boulety Québec Heart and Lung Institute-Laval University, Québec City, Canada
, MD, PhD,
Giorgio Walter Canonicaf Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy;g IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy;z Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
, MD,
Lawrence Dubuskeaa Division of Allergy and Immunology, Department of Internal Medicine, George Washington University School of Medicine and Health Sciences, George Washington University Medical Faculty Associates, Washington, DC, USA
, MD, PhD,
Carlos Nunesbb Centro de ImmunoAlergologia de Algarve, Porto, Portugal
, MD, PhD,
Juan Carlos Ivancevichcc Immunology Department, Faculty of Medicine, del Salvador University, Buenos Aires, Argentina
, MD, PhD,
Pierachille Santusdd Department of Biomedical and Clinical Sciences, University of Milan, Division of Respiratory Diseases "L. Sacco" Hospital, ASST Fatebenefratelli Sacco, Milan, ItalyORCID Iconhttps://orcid.org/0000-0003-3462-8253
, MD, PhDORCID Icon,
Nelson Rosarioee Federal University of Paraná (UFPR), Curitiba, Brazil
, MD, PhD,
Alexander Emelyanovff Department of Respiratory Medicine, North-Western Medical University named after I.I.Mechnikov, St-Petersburg, Russia
, MD &
Paschalis Steiropoulosgg Department of Respiratory Medicine, Medical School, Democritus University of Thrace, University General Hospital Dragana, Alexandroupolis, Greece
, MD, PhD show all
Pages 2402-2412 | Received 07 Nov 2021, Accepted 20 Dec 2021, Published online: 11 Jan 2022
 
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Abstract

Objective: The optimal use of drug combinations for the management of asthma is providing significant results. This has prompted Interasma (Global Asthma Association) to take a position on inhaled triple therapy in asthma.Methods: We performed an extensive literature research to clinical trials, meta-analyses, randomized controlled trials and systematic reviews.Results: Starting from an extensive literature review, Interasma executive committee discussed and approved this Manifesto, developed by Interasma scientific network (INES) members.Conclusions: The manifesto describes the evidence gathered to date and states, advocates, and proposes issues on inhaled corticosteroid (ICS) plus long-acting beta 2 agonist (LABA) and long-acting muscarinic antagonists (LAMA) with the aim of challenging assumptions, fostering commitment, and bringing about change.

Funding

The author(s) reported there is no funding associated with the work featured in this article.

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