Abstract
Purpose
This study aimed to analyze the risk factors affecting lung function in children with asthma based on clinical data to advice on clinical treatment and prognosis.
Methods
This study included newly diagnosed patients with asthma admitted to the Respiratory Department of Chengdu Women’s and Children’s Central Hospital in Sichuan from July 2020 to June 2021. The factors associated with lung function were analyzed using univariate and multivariate linear regression with the forward method, while factors affecting lung ventilation function were analyzed using multivariate logistic regression.
Results
Sixty percent of the patients had normal lung function. Age was significantly negatively correlated with forced vital capacity (FVC)/FVCpredicted (B = –1.385, p = 0.001), FEV1/FEV1predicted (B = –2.092, p < 0.001), and FEV1%/FEV1%predicted (B = –0.834, p = 0.001). Body mass index (BMI) for age Z score (B = 1.661, p = 0.045) and cesarean delivery (B = 4.471, p = 0.013) were significantly positively correlated with FVC/FVCpredicted. Birth weight was significantly positively correlated with FEV1/FEV1predicted (B = 4.593, p = 0.027). Multivariate logistic regression analysis revealed that age ≥6 years and cough variant asthma (CVA) were risk factors for abnormal lung function.
Conclusions
Age, BMI for age Z score, mode of delivery, and birth weight were significantly correlated with lung function in children with asthma. Furthermore, children with asthma and normal lung function were more likely to be overlooked. More attention should be given to children with asthma and normal lung function, and CVA.
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Acknowledgments
We wish to thank all the staff of Chengdu Women’s and Children’s Central Hospital in Sichuan who have contributed to this study. We also thank Shanghai Synyi Medical Technology Co., Ltd. for providing a data analysis and statistical platform.
Declaration of interest
The authors declared that there was no conflict of interest associated with the manuscript.