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Abstract
The objective of the present study was to examine whether subchronic small-dose exposure to chlorfenvinphos, a commonly used pesticide in Poland, may induce changes in the activities of liver antioxidative enzymes and cause an increase in liver malonyldialdehyde level. The animals received once daily 0.1 mL per 100 g of olive oil (control groups) and oil solution of chlorfenvinphos at a dose of 0.02 LD50–the experimental groups. The animals were sacrificed on day 14 and day 28 of the exposure. In the serum cholinesterase activity and in the liver activities of catalase, superoxide dismutase and glutathione peroxidase as well as malonyldialdehyde level were determined. The study revealed that, apart from the inhibitory effects of subchronic chlorfenvinphos administration on serum cholinesterases, this insecticide increased oxidative stress in the liver, which was manifested by antioxidative enzyme activities and enhanced level of lipid peroxidation marker. Moreover liver oxidative stress has been observed in the absence of depressed cholinestaerase level. It is concluded, that in chronic exposure to organophosphates, apart from serum cholinesterase activity the monitoring of parameters of oxidative stress as a new biomarker must be taken into consideration.