Alteration of body total antioxidant capacity and thiol molecules in human chronic exposure to aluminum

Abstract

The physiological role of aluminum (Al) is not yet known. Exposure to Al may cause many human disorders. The aim of this study was to explore how occupational human exposure to Al might affect the body oxidative stress. The relation between Al toxicity and oxidative stress was studied in blood samples obtained from 45 primary Al production workers, with a minimum work history of three years in the age range of 29–52 years. They were evaluated for oxidative stress biomarkers including thiobarbituric acid reactive substances (TBARS) indicator of lipid peroxidation, ferric reducing ability of plasma (FRAP) indicator of total antioxidant capacity, total thiol molecules and Al level in blood. The results showed that workers have significantly higher blood Al levels and concomitant lower blood FRAP and total thiol molecules in comparison to controls. Smokers had lower total thiol molecules than non-smokers. The subjects who had a previous history of disease had lower FRAP levels. It is concluded that Al induces oxidative stress in primary Al production workers. Supplementation of workers with antioxidants may have beneficial effects.

Keywords:

• aluminum
• oxidative stress
• workers
• lipid peroxidation
• total antioxidant capacity

Acknowledgements

This study was supported by a grant from the Arak University of Medical Sciences. This study was presented at the 16th Congress of Pharmacology in China and its abstract was published in Acta Pharmacologica Sinica 27: 446–446 Suppl. 1, July 2006.