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Toxicological & Environmental Chemistry Volume 90, 2008 - Issue 4
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Original Articles

In vitro genotoxicity of extracellular extract from Nostoc piscinale

Eshrat Gharaei-Fathabad Faculty of Pharmacy, Department of Pharmacognosy and Biotechnology, Mazandaran University of Medical Sciences, Sari 48175/861, IranCorrespondence[email protected]
,
Mojtaba Tabatabaei Yazdi Faculty of Pharmacy, Biotechnology Research Center, Department of Pharmaceutical Biotechnology, Medical Sciences, University of Tehran, Tehran, 14174, Iran
,
Seyed-Nasser Ostad Faculty of Pharmacy, Medicinal Plant Research Center, Department of Toxicology and Pharmacology, Medical Sciences, University of Tehran, Tehran, 141155, Iran
&
Mohammad Ali Faramarzi Faculty of Pharmacy, Biotechnology Research Center, Department of Pharmaceutical Biotechnology, Medical Sciences, University of Tehran, Tehran, 14174, Iran
Pages 795-799 | Received 04 Oct 2007, Accepted 11 Oct 2007, Published online: 20 Oct 2008
 
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Abstract

The extracellular extract obtained from 3 weeks incubation of the soil isolate cyanobacterium strain Nostoc piscinale GT-319 in BG-11 broth medium showed cytotoxic activity against Chinese Hamster Ovary (CHO) cells. Based on comet assay, a concentration of 333 µg mL−1 (IC50) produced DNA breakages in CHO cells. The concentration of 481 mg kg−1 (LD50) produced acute toxicity in mice at 48 h.

Acknowledgement

This work was financially supported by a grant from the Medical Sciences/University of Tehran.

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